Darutoside is an orally effective diterpene compound with significant anti-inflammatory, analgesic, wound healing promotion, and immunomodulatory activities. It reduces edema and pain by inhibiting COX-2 expression and inflammatory cell migration, and regulates macrophage polarization towards the M2 type by inhibiting the NF-κB pathway, which alleviates inflammation and promotes wound healing. Additionally, it significantly alleviates acute gouty arthritis through multi-target regulation of metabolic networks.
- Inhibits COX-2 expression
- Inhibits NF-κB pathway
- Regulates macrophage polarization towards the M2 type
- Reduces edema and pain
- Promotes wound healing
- Alleviates acute gouty arthritis